Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Iron dyshomeostasis is implicated in Alzheimer's disease (AD) alongside β-amyloid and tau
pathologies. Despite the recent discovery of ferroptosis, an iron-dependent form cell death …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …

Alzheimer's disease (AD) is a major subtype of neurodegenerative dementia caused by long-
term interactions and accumulation of multiple adverse factors, accompanied by …

Metal homeostasis in the central nervous system (CNS) is a crucial component of healthy
brain function, because metals serve as enzymatic cofactors and are key components of …

Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Intercellular communication refers to the different ways through which cells communicate
with each other and transfer a variety of messages. These communication methods involve a …

With the industrial development and progressive increase in environmental pollution, the
mankind overexposure to heavy metals emerges as a pressing public health issue …