Inverse cubic and hexagonal mesophase evolution within ionizable lipid nanoparticles correlates with mRNA transfection in macrophages
mRNA lipid nanoparticle (LNP) technology presents enormous opportunities to prevent and
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …
[HTML][HTML] Evolution of the structure of lipid nanoparticles for nucleic acid delivery: From in situ studies of formulation to colloidal stability
The development of lipid nanoparticle (LNP) based therapeutics for delivery of RNA has
triggered the advance of new strategies for formulation, such as high throughput …
triggered the advance of new strategies for formulation, such as high throughput …
Nanotechnology of inhalable vaccines for enhancing mucosal immunity
L Qin, Y Sun, N Gao, G Ling, P Zhang - Drug Delivery and Translational …, 2024 - Springer
Vaccines are the cornerstone of world health. The majority of vaccines are formulated as
injectable products, facing the drawbacks of cold chain transportation, needle-stick injuries …
injectable products, facing the drawbacks of cold chain transportation, needle-stick injuries …
Recent advances in synchrotron scattering methods for probing the structure and dynamics of colloids
T Narayanan - Advances in Colloid and Interface Science, 2024 - Elsevier
Recent progress in synchrotron based X-ray scattering methods applied to colloid science is
reviewed. An important figure of merit of these techniques is that they enable in situ …
reviewed. An important figure of merit of these techniques is that they enable in situ …
Angiopep-2-Functionalized Lipid Cubosomes for Blood–Brain Barrier Crossing and Glioblastoma Treatment
Glioblastoma multiforme (GBM) is an aggressive brain cancer with high malignancy and
resistance to conventional treatments, resulting in a bleak prognosis. Nanoparticles offer a …
resistance to conventional treatments, resulting in a bleak prognosis. Nanoparticles offer a …
pH‐Dependent Lyotropic Liquid Crystalline Mesophase and Ionization Behavior of Phytantriol‐Based Ionizable Lipid Nanoparticles
Self‐assembled lipid nanoparticles (LNPs), serving as essential nanocarriers in recent
COVID‐19 mRNA vaccines, provide a stable and versatile platform for delivering a wide …
COVID‐19 mRNA vaccines, provide a stable and versatile platform for delivering a wide …
[HTML][HTML] Regulating the structural polymorphism and protein corona composition of phytantriol-based lipid nanoparticles using choline ionic liquids
Lipid-based lyotropic liquid crystalline nanoparticles (LCNPs) face stability challenges in
biological fluids during clinical translation. Ionic Liquids (ILs) have emerged as effective …
biological fluids during clinical translation. Ionic Liquids (ILs) have emerged as effective …
Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process Parameters
Lipid nanoparticles (LNPs) have proven to be promising delivery vehicles for RNA-based
vaccines and therapeutics, particularly in LNP formulations containing ionizable cationic …
vaccines and therapeutics, particularly in LNP formulations containing ionizable cationic …
Mesoscopic Structure of Lipid Nanoparticle Formulations for mRNA Drug Delivery: Comirnaty and Drug-Free Dispersions
T Unruh, K Götz, C Vogel, E Fröhlich, A Scheurer… - ACS …, 2024 - ACS Publications
Lipid nanoparticles (LNPs) produced by antisolvent precipitation (ASP) are used in
formulations for mRNA drug delivery. The mesoscopic structure of such complex …
formulations for mRNA drug delivery. The mesoscopic structure of such complex …
Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages
J Iscaro, H Yu, N Martinez… - Advanced Functional …, 2024 - Wiley Online Library
Macrophages are unique immune cells attracting growing attention as a potential candidate
for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme …
for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme …