Inverse cubic and hexagonal mesophase evolution within ionizable lipid nanoparticles correlates with mRNA transfection in macrophages

H Yu, J Iscaro, B Dyett, Y Zhang, S Seibt… - Journal of the …, 2023 - ACS Publications
mRNA lipid nanoparticle (LNP) technology presents enormous opportunities to prevent and
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …

[HTML][HTML] Evolution of the structure of lipid nanoparticles for nucleic acid delivery: From in situ studies of formulation to colloidal stability

J Gilbert, F Sebastiani, MY Arteta, A Terry… - Journal of colloid and …, 2024 - Elsevier
The development of lipid nanoparticle (LNP) based therapeutics for delivery of RNA has
triggered the advance of new strategies for formulation, such as high throughput …

Nanotechnology of inhalable vaccines for enhancing mucosal immunity

L Qin, Y Sun, N Gao, G Ling, P Zhang - Drug Delivery and Translational …, 2024 - Springer
Vaccines are the cornerstone of world health. The majority of vaccines are formulated as
injectable products, facing the drawbacks of cold chain transportation, needle-stick injuries …

Recent advances in synchrotron scattering methods for probing the structure and dynamics of colloids

T Narayanan - Advances in Colloid and Interface Science, 2024 - Elsevier
Recent progress in synchrotron based X-ray scattering methods applied to colloid science is
reviewed. An important figure of merit of these techniques is that they enable in situ …

Angiopep-2-Functionalized Lipid Cubosomes for Blood–Brain Barrier Crossing and Glioblastoma Treatment

X Cai, A Refaat, PY Gan, B Fan, H Yu… - … Applied Materials & …, 2024 - ACS Publications
Glioblastoma multiforme (GBM) is an aggressive brain cancer with high malignancy and
resistance to conventional treatments, resulting in a bleak prognosis. Nanoparticles offer a …

pH‐Dependent Lyotropic Liquid Crystalline Mesophase and Ionization Behavior of Phytantriol‐Based Ionizable Lipid Nanoparticles

H Yu, B Dyett, N Kirby, X Cai, ME Mohamad… - Small, 2024 - Wiley Online Library
Self‐assembled lipid nanoparticles (LNPs), serving as essential nanocarriers in recent
COVID‐19 mRNA vaccines, provide a stable and versatile platform for delivering a wide …

[HTML][HTML] Regulating the structural polymorphism and protein corona composition of phytantriol-based lipid nanoparticles using choline ionic liquids

M El Mohamad, Q Han, AJ Clulow, C Cao… - Journal of Colloid and …, 2024 - Elsevier
Lipid-based lyotropic liquid crystalline nanoparticles (LCNPs) face stability challenges in
biological fluids during clinical translation. Ionic Liquids (ILs) have emerged as effective …

Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process Parameters

A Kamanzi, Y Zhang, Y Gu, F Liu, R Berti, B Wang… - ACS …, 2024 - ACS Publications
Lipid nanoparticles (LNPs) have proven to be promising delivery vehicles for RNA-based
vaccines and therapeutics, particularly in LNP formulations containing ionizable cationic …

Mesoscopic Structure of Lipid Nanoparticle Formulations for mRNA Drug Delivery: Comirnaty and Drug-Free Dispersions

T Unruh, K Götz, C Vogel, E Fröhlich, A Scheurer… - ACS …, 2024 - ACS Publications
Lipid nanoparticles (LNPs) produced by antisolvent precipitation (ASP) are used in
formulations for mRNA drug delivery. The mesoscopic structure of such complex …

Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages

J Iscaro, H Yu, N Martinez… - Advanced Functional …, 2024 - Wiley Online Library
Macrophages are unique immune cells attracting growing attention as a potential candidate
for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme …