Nucleic acids display remarkable properties beyond information storage and propagation.
The well-understood base pairing rules have enabled nucleic acids to be assembled into …

Nucleic acid aptamers generated through an in vitro selection are currently extensively
applied as very valuable biomolecular tools thanks to their prominent advantages. Diversity …

Synthetically directing T‐cells against tumors emerges as a promising strategy in
immunotherapy, while it remains challenging to smartly engage T cells with tunable immune …

Aptamers are short and single-stranded DNA or RNA molecules with highly programmable
structures that give them the ability to interact specifically with a large variety of targets …

Poor efficacy and off-target systemic toxicity are major problems associated with current
chemotherapeutic approaches to treat cancer. We developed a new form of polyvalent …

Signal amplification strategies have attracted considerable attention due to the growing
demands for ultrasensitive bioassays. Here, we summarize the latest developments in the …

Capture and analysis of circulating tumor cells (CTCs) from complex matrixes is pivotal for
the prediction of cancer metastasis and personalized treatment of cancer. Herein, we …

In the past two decades, aptamers have emerged as a novel class of molecular recognition
probes comprising uniquely-folded short RNA or single-stranded DNA oligonucleotides that …

Multivalency is nature's way to establish firm and specific interactions when the binding sites
of a protein receptor have only low affinity for monovalent ligands. Recently, researchers are …

Circulating tumor cells (CTCs) enable noninvasive liquid biopsy and identification of cancer.
Various approaches exist for the capture and release of CTCs, including microfluidic …