Circular nucleic acids: Discovery, functions and applications

J Li, M Mohammed‐Elsabagh, F Paczkowski… - …, 2020 - Wiley Online Library
Circular nucleic acids (CNAs) are nucleic acid molecules with a closed‐loop structure. This
feature comes with a number of advantages including complete resistance to exonuclease …

Microfluidic sample preparation for diagnostic cytopathology

AJ Mach, OB Adeyiga, D Di Carlo - Lab on a Chip, 2013 - pubs.rsc.org
The cellular components of body fluids are routinely analyzed to identify disease and
treatment approaches. While significant focus has been placed on developing cell analysis …

RNAi‐microsponges form through self‐assembly of the organic and inorganic products of transcription

KE Shopsowitz, YH Roh, ZJ Deng, SW Morton… - Small, 2014 - Wiley Online Library
Inorganic nanostructures have been used extensively to package nucleic acids into forms
useful for therapeutic applications. Here we report that the two products of transcription, RNA …

Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands

K Zhang, R Deng, Y Sun, L Zhang, J Li - Chemical science, 2017 - pubs.rsc.org
Chemically functionalized and nanostructured materials, which mimic the features of the
natural extracellular matrix, provide a tool to organize cell surface receptors into nanoscale …

Filter‐based isolation, enrichment, and characterization of circulating tumor cells

S Khetani, M Mohammadi… - Biotechnology and …, 2018 - Wiley Online Library
Isolation of circulating tumor cells (CTCs) from blood has long been a challenge due to the
rarity and heterogeneity of these cells. Detection technologies have predominantly focused …

Electrochemical aptasensor for exosomal proteins profiling based on DNA nanotetrahedron coupled with enzymatic signal amplification

J Jiang, Y Yu, H Zhang, C Cai - Analytica Chimica Acta, 2020 - Elsevier
Exosomes are extracellular nanovesicles for transferring and delivering membrane and
cytosolic molecules between cells. Detection and profiling of exosomal proteins can provide …

Regenerative NanoOctopus based on multivalent-aptamer-functionalized magnetic microparticles for effective cell capture in whole blood

Y Chen, D Tyagi, M Lyu, AJ Carrier, C Nganou… - Analytical …, 2019 - ACS Publications
Isolation of specific rare cell subtypes from whole blood is critical in cellular analysis and
important in basic and clinical research. Traditional immunomagnetic cell capture suffers …

Effects of nanopillar array diameter and spacing on cancer cell capture and cell behaviors

S Wang, Y Wan, Y Liu - Nanoscale, 2014 - pubs.rsc.org
While substrates with nanopillars (NPs) have emerged as promising platforms for isolation of
circulating tumor cells (CTCs), the influence of diameter and spacing of NPs on CTC capture …

Aptamer-functionalized nano/micro-materials for clinical diagnosis: isolation, release and bioanalysis of circulating tumor cells

Y Zhao, D Xu, W Tan - Integrative biology, 2017 - academic.oup.com
Detection of rare circulating tumor cells (CTCs) in peripheral blood is a challenging, but
necessary, task in order to diagnose early onset of metastatic cancer and to monitor …

Improving performance of cell imprinted PDMS by integrating boronate affinity and local post-imprinting modification for selective capture of circulating tumor cells from …

Y Sun, Y Luo, L Sun, XR Wang, LW Chen… - Biosensors and …, 2023 - Elsevier
Efficient capture of circulating tumor cells (CTCs) from cancer patients is an important
technique that may promote early diagnosis and prognosis monitoring of cancer. However …