Fungal endophytes as efficient sources of plant-derived bioactive compounds and their prospective applications in natural product drug discovery: Insights, avenues …

A Singh, DK Singh, RN Kharwar, JF White, SK Gond - Microorganisms, 2021 - mdpi.com
Fungal endophytes are well-established sources of biologically active natural compounds
with many producing pharmacologically valuable specific plant-derived products. This …

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

S Wolf, J Becker, Y Tsuge, H Kawaguchi… - Essays in …, 2021 - portlandpress.com
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial
biotechnology and has become famous for its power to synthetise amino acids and a range …

[HTML][HTML] Salidroside ameliorates Alzheimer's disease by targeting NLRP3 inflammasome-mediated pyroptosis

Y Cai, Y Chai, Y Fu, Y Wang, Y Zhang… - Frontiers in aging …, 2022 - frontiersin.org
Amyloid β-protein (Aβ) is reported to activate NLRP3 inflammasomes drive to pyroptosis,
which is subsequently involved in the pathogenesis of neurodegenerative diseases, such as …

Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications

H Xu, E Wang, F Chen, J Xiao… - Oxidative Medicine and …, 2021 - Wiley Online Library
Ischemic stroke is a challenging disease with high mortality and disability rates, causing a
great economic and social burden worldwide. During ischemic stroke, ionic imbalance and …

Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer's disease mice and glutamate-injured HT22 …

S Yang, Z Xie, T Pei, Y Zeng, Q Xiong, H Wei, Y Wang… - Chinese Medicine, 2022 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disease. Ferroptosis plays a
critical role in neurodegenerative diseases. Nuclear factor E2-related factor 2 (Nrf2) is …

[HTML][HTML] Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review

D Zhao, K Yang, H Guo, J Zeng, S Wang, H Xu… - Biomedicine & …, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

[HTML][HTML] Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice

S Yang, L Wang, Y Zeng, Y Wang, T Pei, Z Xie, Q Xiong… - Phytomedicine, 2023 - Elsevier
Background Alzheimer's disease (AD) is a neurogenerative disease and remains no
effective method for stopping its progress. Ferroptosis and adaptive immunity have been …

[HTML][HTML] Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety

F Fan, L Yang, R Li, X Zou, N Li, X Meng… - Biomedicine & …, 2020 - Elsevier
Salidroside (Sal) is a bioactive extract principally from traditional herbal medicine such as
Rhodiola rosea L., which has been commonly used for hundreds of years in Asia countries …

Salidroside attenuates cognitive dysfunction in senescence-accelerated mouse prone 8 (SAMP8) mice and modulates inflammation of the gut-brain axis

Z Xie, H Lu, S Yang, Y Zeng, W Li, L Wang… - Frontiers in …, 2020 - frontiersin.org
Background: Alzheimer's disease (AD) is a fatal neurodegenerative disease characterized
by progressive cognitive decline and memory loss. However, several therapeutic …

Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

F Limanaqi, F Biagioni, CL Busceti, M Polzella… - Antioxidants, 2020 - mdpi.com
Recent studies focused on the pharmacology and feasibility of herbal compounds as a
potential strategy to target a variety of human diseases ranging from metabolic to brain …