Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …

Polyglutamine spinocerebellar ataxias (SCAs) comprise a heterogeneous group of six
autosomal dominant ataxias caused by cytosine–adenine–guanine repeat expansions in …

Spinocerebellar ataxias (SCAs) represent a large group of hereditary degenerative diseases
of the nervous system, in particular the cerebellum, and other systems that manifest with a …

Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease mainly
characterized by motor incoordination because of progressive cerebellar degeneration …

Spinocerebellar ataxias (SCAs) are a heterogenous group of neurodegenerative disorders
which commonly inherited in an autosomal dominant manner. They cause muscle …

Increasing reports suggest insulin signalling pathway as a putative drug target against
polyglutamine [poly (Q)] disorders, such as Huntington's disease (HD), Spinocerebellar …

Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited
neurodegenerative disease caused by CAG repeat expansion in the first coding exon of the …

Background Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that
primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in …

Adeno-associated virus (AAV) vectors have become an attractive tool for efficient gene
transfer into animal tissues. Extensively studied as the vehicles for therapeutic constructs in …

Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological
expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic …