ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies

AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Challenges and hopes for Alzheimer's disease

SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases

NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

The potential role of gut microbiota in Alzheimer's disease: from diagnosis to treatment

A Varesi, E Pierella, M Romeo, GB Piccini, C Alfano… - Nutrients, 2022 - mdpi.com
Gut microbiota is emerging as a key regulator of many disease conditions and its
dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal …

Impact of a ketogenic diet on metabolic parameters in patients with obesity or overweight and with or without type 2 diabetes: a meta-analysis of randomized controlled …

YJ Choi, SM Jeon, S Shin - Nutrients, 2020 - mdpi.com
The aim of this meta-analysis was to explore the efficacy of a ketogenic diet in metabolic
control in patients with overweight or obesity and with or without type 2 diabetes. Embase …

Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome

C Kong, X Yan, Y Liu, L Huang, Y Zhu, J He… - Signal transduction and …, 2021 - nature.com
Accumulating evidence suggests that ketogenic diets (KDs) mediate the rise of circulating
ketone bodies and exert a potential anti-inflammatory effect; however, the consequences of …

Disorders of the enteric nervous system—a holistic view

B Niesler, S Kuerten, IE Demir… - … reviews Gastroenterology & …, 2021 - nature.com
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …

Ketogenic diet and epilepsy

M Ułamek-Kozioł, SJ Czuczwar, S Januszewski… - Nutrients, 2019 - mdpi.com
Currently available pharmacological treatment of epilepsy has limited effectiveness. In
epileptic patients, pharmacological treatment with available anticonvulsants leads to seizure …

Ketogenic diet: a dietary intervention via gut microbiome modulation for the treatment of neurological and nutritional disorders (a narrative review)

JM Lim, V Letchumanan, LTH Tan, KW Hong, SH Wong… - Nutrients, 2022 - mdpi.com
The ketogenic diet (KD) has been important in treating epilepsy since the 1920s. The
benefits of KD further expanded to other neurological diseases, including Alzheimer's …