ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
Challenges and hopes for Alzheimer's disease
SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …
effective disease-modifying agents for many reasons, including the substantial …
Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases
NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
The potential role of gut microbiota in Alzheimer's disease: from diagnosis to treatment
A Varesi, E Pierella, M Romeo, GB Piccini, C Alfano… - Nutrients, 2022 - mdpi.com
Gut microbiota is emerging as a key regulator of many disease conditions and its
dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal …
dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal …
Impact of a ketogenic diet on metabolic parameters in patients with obesity or overweight and with or without type 2 diabetes: a meta-analysis of randomized controlled …
YJ Choi, SM Jeon, S Shin - Nutrients, 2020 - mdpi.com
The aim of this meta-analysis was to explore the efficacy of a ketogenic diet in metabolic
control in patients with overweight or obesity and with or without type 2 diabetes. Embase …
control in patients with overweight or obesity and with or without type 2 diabetes. Embase …
Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome
C Kong, X Yan, Y Liu, L Huang, Y Zhu, J He… - Signal transduction and …, 2021 - nature.com
Accumulating evidence suggests that ketogenic diets (KDs) mediate the rise of circulating
ketone bodies and exert a potential anti-inflammatory effect; however, the consequences of …
ketone bodies and exert a potential anti-inflammatory effect; however, the consequences of …
Disorders of the enteric nervous system—a holistic view
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …
and closely resembles components and functions of the central nervous system. Although …
Ketogenic diet and epilepsy
M Ułamek-Kozioł, SJ Czuczwar, S Januszewski… - Nutrients, 2019 - mdpi.com
Currently available pharmacological treatment of epilepsy has limited effectiveness. In
epileptic patients, pharmacological treatment with available anticonvulsants leads to seizure …
epileptic patients, pharmacological treatment with available anticonvulsants leads to seizure …
Ketogenic diet: a dietary intervention via gut microbiome modulation for the treatment of neurological and nutritional disorders (a narrative review)
The ketogenic diet (KD) has been important in treating epilepsy since the 1920s. The
benefits of KD further expanded to other neurological diseases, including Alzheimer's …
benefits of KD further expanded to other neurological diseases, including Alzheimer's …