Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Mitochondria serve numerous critical cellular functions, rapidly responding to extracellular
stimuli and cellular demands while dynamically communicating with other organelles …

Mammalian developmental timing is adjustable in vivo by preserving pre-implantation
embryos in a dormant state called diapause. Inhibition of the growth regulator mTOR …

Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …

FOXO family of proteins are transcription factors involved in many physiological and
pathological processes including cellular homeostasis, stem cell maintenance, cancer …

Mitochondria play essential roles in cellular energetics, biosynthesis, and signaling
transduction. Dysfunctional mitochondria have been implicated in different diseases such as …

Changes in metabolic pathways are often associated with the development of various
pathologies including cancer, inflammatory diseases, obesity and metabolic syndrome …

Long dismissed as merely harmful respiratory by-products, Reactive Oxygen Species (ROS)
have emerged as critical intracellular messengers during cell growth and differentiation …

Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal
cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying …

Undue elevation of ROS levels commonly occurs during cancer evolution as a result of
various antitumor therapeutics and/or endogenous immune response. Overwhelming ROS …