[HTML][HTML] The genetic changes of hepatoblastoma

H Chen, Q Guan, H Guo, L Miao, Z Zhuo - Frontiers in oncology, 2021 - frontiersin.org
Hepatoblastoma is the most common malignant liver cancer in childhood. The etiology of
hepatoblastoma remains obscure. Hepatoblastoma is closely related to genetic syndromes …

[HTML][HTML] Computational tools to detect signatures of mutational processes in DNA from tumours: a review and empirical comparison of performance

H Omichessan, G Severi, V Perduca - PloS one, 2019 - journals.plos.org
Mutational signatures refer to patterns in the occurrence of somatic mutations that might be
uniquely ascribed to particular mutational process. Tumour mutation catalogues can reveal …

Children's Oncology Group's 2023 blueprint for research: Liver tumors

AF O'Neill, RL Meyers, HM Katzenstein… - Pediatric Blood & …, 2023 - Wiley Online Library
Liver tumors account for approximately 1%–2% of all pediatric malignancies, with the two
most common tumors being hepatoblastoma (HB) and hepatocellular carcinoma (HCC) …

Association between lncRNA‐H19 polymorphisms and hepatoblastoma risk in an ethic Chinese population

T Tan, J Li, Y Wen, Y Zou, J Yang, J Pan… - Journal of cellular …, 2021 - Wiley Online Library
H19 polymorphisms are associated with increased susceptibility to several cancers;
however, their role in hepatoblastoma remains unclear. In this study, we investigated the …

Hepatoblastoma in molecularly defined, congenital diseases

G Nussbaumer, M Benesch - American Journal of Medical …, 2022 - Wiley Online Library
Abstract Beckwith–Wiedemann spectrum, Simpson–Golabi–Behmel syndrome, familial
adenomatous polyposis and trisomy 18 are the most common congenital conditions …

Defining an optimal time window to screen for hepatoblastoma in children with Beckwith‐Wiedemann syndrome

A Mussa, KA Duffy, D Carli, GB Ferrero… - Pediatric blood & …, 2019 - Wiley Online Library
Abstract Patients with Beckwith‐Wiedemann spectrum (BWSp) undergo quarterly alpha‐
fetoprotein measurement for hepatoblastoma (HB) screening up to 4 years of age …

[HTML][HTML] Unraveling the genetic architecture of hepatoblastoma risk: birth defects and increased burden of germline damaging variants in gastrointestinal/renal cancer …

T Aguiar, A Teixeira, MO Scliar… - Frontiers in …, 2022 - frontiersin.org
The ultrarare hepatoblastoma (HB) is the most common pediatric liver cancer. HB risk is
related to a few rare syndromes, and the molecular bases remain elusive for most cases. We …

METTL14 gene polymorphisms influence hepatoblastoma predisposition in Chinese children: Evidences from a seven-center case-control study

H Chen, Z Chen, M Wang, J Zhang, Y Li, L Li, S Li… - Gene, 2022 - Elsevier
Hepatoblastoma as the most prevalent hepatic malignancy in children, its etiology remains
unclear. N 6-Methyladenosine (m 6 A) modification which can modify various physiological …

Polymorphisms in METTL3 gene and hepatoblastoma risk in Chinese children: A seven-center case-control study

H Chen, F Duan, M Wang, J Zhu, J Zhang, J Cheng… - Gene, 2021 - Elsevier
Hepatoblastoma is the most common malignant liver cancer in childhood, yet its etiology
remains unclear. As an m 6 A methylation modifier, methyltransferase like 3 (METTL3) has …

[HTML][HTML] NRAS and KRAS polymorphisms are not associated with hepatoblastoma susceptibility in Chinese children

T Yang, Y Wen, J Li, T Tan, J Yang, J Pan, C Hu… - … Hematology & Oncology, 2019 - Springer
Background Hepatoblastoma is the most common hepatic malignancy in children,
accounting for approximately 80% of all childhood liver tumors. KRAS and NRAS, members …