The transcription of iron uptake and storage genes in Saccharomyces cerevisiae is primarily
regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent …

Glutaredoxins, proteins traditionally involved in redox reactions, are also required for iron–
sulfur cluster assembly and haem biosynthesis. These new roles are probably related to the …

Abstract Significance: Glutaredoxin (Grx) is the primary enzyme responsible for catalysis of
deglutathionylation of protein-mixed disulfides with glutathione (GSH)(protein-SSG). This …

During the 70s and 80s two plant thioredoxin systems were identified. The chloroplastic
system is composed of a ferredoxin-dependent thioredoxin, with two thioredoxin types (m …

Abstract Significance: Glutaredoxins (Grxs) are small oxidoreductases of the thioredoxin
family of proteins regulating the thiol redox state of several proteins. Thereby, Grxs are key …

Despite their very close structural similarity, CxxC/S-type (class I) glutaredoxins (Grxs) act as
oxidoreductases, while CGFS-type (class II) Grxs act as FeS cluster transferases. Here we …

The mitochondrial Hsp70 chaperone Ssq1 plays a dedicated role in the maturation of iron–
sulfur (Fe/S) proteins, an essential process of mitochondria. Similar to its bacterial …

The biogenesis of iron–sulfur (Fe–S) proteins in humans is a multistage process occurring in
different cellular compartments. The mitochondrial iron–sulfur cluster (ISC) assembly …

Iron–sulfur (Fe–S) clusters are present in more than 200 different types of enzymes or
proteins and constitute one of the most ancient, ubiquitous and structurally diverse classes …

Significance: In photosynthetic organisms, besides the well-established disulfide/dithiol
exchange reactions specifically controlled by thioredoxins (TRXs), protein S …