BACKGROUND: In biological systems, redox reactions are central to most cellular
processes and the redox potential of the intracellular compartment dictates whether a …

Biogenesis and recycling of iron–sulfur (Fe–S) clusters play important roles in the iron
homeostasis mechanisms involved in mitochondrial function. In Saccharomyces cerevisiae …

Glutaredoxins are small proteins of the thioredoxin superfamily that are present throughout
life. Most glutaredoxins fall into two major subfamilies. Class I glutaredoxins are glutathione …

The expression of iron transport genes in Schizosaccharomyces pombe is controlled by the
Fep1 transcription factor. When iron levels exceed those needed by the cells, Fep1 …

Chagas Disease, African sleeping sickness, and leishmaniasis are neglected diseases
caused by pathogenic trypanosomatid parasites, which have a considerable impact on …

Previous studies have identified a putative mycothiol peroxidase (MPx) in Corynebacterium
glutamicum that shared high sequence similarity to sulfur-containing Gpx (glutathione …

ABSTRACT Saccharomyces cerevisiae Grx6 and Grx7 are two monothiol glutaredoxins
whose active-site sequences (CSYS and CPYS, respectively) are reminiscent of the CPYC …

Glutaredoxins (Grx) are involved in many reactions including defense against oxidative
stress. However, the role of the Grx system under nitrosative stress has barely been …

Glutaredoxins (Grxs), ubiquitous redox enzymes belonging to the thioredoxin family,
catalyze the reduction of thiol-disulfide exchange reactions in a glutathione-dependent …

Glutaredoxins (Grxs), the oxidoreductase proteins, are involved in several cellular
processes, including maintenance of cellular redox potential and iron-sulfur homeostasis …