Monothiol glutaredoxins (Grxs) with a noncanonical CGFS active site are found in all
kingdoms of life. They include members with a single domain and thioredoxin-Grx fusion …

Fe–S clusters are ensembles of sulphide-linked di-, tri-, and tetra-iron centres of a variety of
metalloproteins that play important roles in reduction and oxidation of mitochondrial electron …

Disulfide bonds play a critical role in a variety of structural and mechanistic processes
associated with proteins inside the cells and in the extracellular environment. The …

Two dithiol glutaredoxins (Grxs), Grx1 and Grx2, from yeast have been characterized to date.
A third putative dithiol glutaredoxin-encoding gene (GRX8) has been identified in silico …

Cytosolic monothiol glutaredoxins (GRX s) are required in iron-sulfur (Fe-S) cluster delivery
and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar …

Unlike in higher organisms, selenium is not essential for growth in Saccharomyces
cerevisiae. In this species, it causes toxic effects at high concentrations. In the present study …

Arabidopsis monothiol glutaredoxin (Grx), AtGRX4, was targeted to chloroplasts/plastids and
had high similarity to yeast Grx5. In yeast expression assays, AtGRX4 localized to the …

Abstract Glutaredoxin 3 (Grx3), a redox protein with a thioredoxin-fold structure, maintains
structural integrity and glutathione (GSH) binding capabilities across varying habitat …

Trypanosomatids are mainly responsible for heterogeneous parasitic diseases:
Leishmaniasis, Sleeping sickness, and Chagas disease and control of these diseases …

Abstract Aims: Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular
iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African …