Aging is a major risk factor for neurodegenerative diseases including Alzheimer's disease
(AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced …

Background Neuroinflammation characterized by glial activation and release of
proinflammatory mediators is considered to play a critical role in the pathogenesis of …

Background Oxidation, inflammation, and apoptosis are three critical factors for the
pathogenic mechanism of cerebral ischemia/reperfusion (I/R) injury. Curcumin exhibits …

Aims/hypothesis We have provided evidence that glucagon-like peptide-1, a potential
therapeutic agent in the treatment of diabetes, activates phosphatidylinositol-3 …

Schwann cell–derived exosomes communicate with dorsal root ganglia (DRG) neurons. The
current study investigated the therapeutic effect of exosomes derived from healthy Schwann …

Oxidative stress is the leading player in the onset and development of various diseases. The
Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells' redox balance. It …

The function of nuclear factor (NF)-κB within the developing and mature CNS is
controversial. We have generated transgenic mice to reveal NF-κB transcriptional activity in …

Purpose Bilberries are abundant in polyphenols. Dietary polyphenols have been associated
with strategies for prevention and treatment of chronic inflammatory diseases. We …

Thrombolysis with tissue-type plasminogen activator (tPA) is used for the treatment of
patients with acute ischemic stroke. However, a growing body of evidence indicates that …

The mechanisms leading to cellular damage from ischemia-reperfusion (I/R) injury are
complex and multi-factorial. Accumulating evidence suggests an important role for oxidative …