The plant-derived steroid, digoxin, a specific inhibitor of Na, K-ATPase, has been used for
centuries in the treatment of heart disease. Recent studies demonstrate the presence of a …

In addition to marshalling immune and inflammatory responses, transcription factors of the
NF-κB family control cell survival. This control is crucial to a wide range of biological …

Background and Purpose—Activation of transcription factor nuclear factor-κB (NF-κB) may
induce expression of either proinflammatory/apoptotic genes or antiapoptotic genes …

Molecular events that result in loss of pain perception are poorly understood in diabetic
neuropathy. Our results show that the receptor for advanced glycation end products (RAGE) …

Ischemic stroke is a leading cause of morbidity and death, with the outcome largely
determined by the amount of hypoxia-related neuronal death in the affected brain regions …

Members of the nuclear factor κB (NF-κB) family of transcription factors are activated within
the CNS in pathological settings of apoptosis and neurological disease. Recent work using …

Observational studies have suggested that lifestyle risk factors such as tobacco, alcohol,
high-fat diet, radiation, and infections can cause cancer and that a diet consisting of fruits …

Since the discovery of nuclear factor-kappa B (NF-κB) in 1986, many studies have been
conducted showing the link between the NF-κB signalling pathway and control of the …

Neuroinflammation occurs early in Alzheimer's disease (AD). The initial stage of AD is
related to glial dysfunction, which contributes to impairment of Aβ clearance and disruption …

A role for the NF-κB family of transcription factors as tumor promoters is firmly established.
However, other data suggest that NF-κB can also inhibit tumor growth. Moreover, NF-κB …