There is growing interest in the possible health threat posed by endocrine-disrupting
chemicals (EDCs), which are substances in our environment, food, and consumer products …

Estrogens have significant direct and indirect effects on prostate gland development and
homeostasis and have been long suspected in playing a role in the etiology of prostatic …

There is increasing evidence both from epidemiology studies and animal models that
specific endocrine-disrupting compounds may influence the development or progression of …

Prostate morphogenesis occurs in utero in humans and during the perinatal period in
rodents. While largely driven by androgens, there is compelling evidence for a permanent …

This article reviews progress in chemopreventive drug development, especially data and
concepts that are new since the 2002 AACR report on treatment and prevention of …

Estrogens have previously been extensively used in prostate cancer treatment. Serious side
effects, primarily in cardiovascular system have, however, limited their use. The therapeutic …

Estrogen reprogramming of the prostate gland as a function of developmental exposures
(aka developmental estrogenization) results in permanent alterations in structure and gene …

PURPOSE: A randomized, double-blind, dose finding, placebo controlled, parallel group
clinical study was done to determine the incidence of prostate cancer in men with high grade …

Antiestrogenic adjuvant treatments are first-line therapies in patients with breast cancer
positive for estrogen receptor (ER+). Improvement of their treatment strategies is needed …

Just like the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the
prostate and is thought to influence prostate cancer (PCa) biology. Yet the incomplete …