Hypertension: do inflammation and immunity hold the key to solving this epidemic?
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
after normalization of blood pressure in patients with hypertension. Underlying immune cell …
The role of B cells in atherosclerosis
AP Sage, D Tsiantoulas, CJ Binder… - Nature Reviews Cardiology, 2019 - nature.com
The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …
Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis–novel insights and future directions in diagnosis and therapy
We provide an up-to-date overview of current topics surrounding oxidized low-density
lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at …
lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at …
Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies
Immune mechanisms are critically involved in the pathogenesis of atherosclerosis and its
clinical manifestations. Associations of specific antibody levels and defined B-cell subsets …
clinical manifestations. Associations of specific antibody levels and defined B-cell subsets …
Colorimetric immunosensor by aggregation of photochemically functionalized gold nanoparticles
A colorimetric immunosensor based on local surface plasmon resonance by gold
nanoparticles is presented, and its application for the detection of human immunoglobulin G …
nanoparticles is presented, and its application for the detection of human immunoglobulin G …
Anti-oxidized LDL antibodies and coronary artery disease: a systematic review
VJ van den Berg, MM Vroegindewey, I Kardys… - Antioxidants, 2019 - mdpi.com
Antibodies to oxidized LDL (oxLDL) may be associated with improved outcomes in
cardiovascular disease. However, analysis is restricted by heterogenous study design and …
cardiovascular disease. However, analysis is restricted by heterogenous study design and …
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis
JA Taylor, MA Hutchinson, PJ Gearhart, RW Maul - Immunity & Ageing, 2022 - Springer
The sequestering of oxidation-modified low-density lipoprotein by macrophages results in
the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes …
the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes …
Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis
G Obermayer, T Afonyushkin, L Göderle… - Blood, The Journal …, 2021 - ashpublications.org
Thrombosis and its associated complications are a major cause of morbidity and mortality
worldwide. Microvesicles (MVs), a class of extracellular vesicles, are increasingly …
worldwide. Microvesicles (MVs), a class of extracellular vesicles, are increasingly …
Increased plasma IgE accelerate atherosclerosis in secreted IgM deficiency
D Tsiantoulas, I Bot, M Ozsvar-Kozma… - Circulation …, 2017 - Am Heart Assoc
Rationale: Deficiency of secreted IgM (sIgM−/−) accelerates atherosclerosis in Ldlr−/− mice.
Several atheroprotective effects of increased levels of IgM antibodies have been suggested …
Several atheroprotective effects of increased levels of IgM antibodies have been suggested …
High levels of (un) switched memory B cells are associated with better outcome in patients with advanced atherosclerotic disease
JAL Meeuwsen, A van Duijvenvoorde… - Journal of the …, 2017 - Am Heart Assoc
Background Atherosclerosis is an inflammatory lipid disorder and the main underlying
pathology of acute ischemic events. Despite a vast amount of data from murine …
pathology of acute ischemic events. Despite a vast amount of data from murine …