Hypertension: do inflammation and immunity hold the key to solving this epidemic?

MS Madhur, F Elijovich, MR Alexander, A Pitzer… - Circulation …, 2021 - Am Heart Assoc
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

The role of B cells in atherosclerosis

AP Sage, D Tsiantoulas, CJ Binder… - Nature Reviews Cardiology, 2019 - nature.com
The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis–novel insights and future directions in diagnosis and therapy

A Hartley, D Haskard, R Khamis - Trends in Cardiovascular Medicine, 2019 - Elsevier
We provide an up-to-date overview of current topics surrounding oxidized low-density
lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at …

Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies

F Porsch, Z Mallat, CJ Binder - Cardiovascular research, 2021 - academic.oup.com
Immune mechanisms are critically involved in the pathogenesis of atherosclerosis and its
clinical manifestations. Associations of specific antibody levels and defined B-cell subsets …

Colorimetric immunosensor by aggregation of photochemically functionalized gold nanoparticles

M Iarossi, C Schiattarella, I Rea, L De Stefano… - ACS …, 2018 - ACS Publications
A colorimetric immunosensor based on local surface plasmon resonance by gold
nanoparticles is presented, and its application for the detection of human immunoglobulin G …

Anti-oxidized LDL antibodies and coronary artery disease: a systematic review

VJ van den Berg, MM Vroegindewey, I Kardys… - Antioxidants, 2019 - mdpi.com
Antibodies to oxidized LDL (oxLDL) may be associated with improved outcomes in
cardiovascular disease. However, analysis is restricted by heterogenous study design and …

Antibodies in action: the role of humoral immunity in the fight against atherosclerosis

JA Taylor, MA Hutchinson, PJ Gearhart, RW Maul - Immunity & Ageing, 2022 - Springer
The sequestering of oxidation-modified low-density lipoprotein by macrophages results in
the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes …

Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis

G Obermayer, T Afonyushkin, L Göderle… - Blood, The Journal …, 2021 - ashpublications.org
Thrombosis and its associated complications are a major cause of morbidity and mortality
worldwide. Microvesicles (MVs), a class of extracellular vesicles, are increasingly …

Increased plasma IgE accelerate atherosclerosis in secreted IgM deficiency

D Tsiantoulas, I Bot, M Ozsvar-Kozma… - Circulation …, 2017 - Am Heart Assoc
Rationale: Deficiency of secreted IgM (sIgM−/−) accelerates atherosclerosis in Ldlr−/− mice.
Several atheroprotective effects of increased levels of IgM antibodies have been suggested …

High levels of (un) switched memory B cells are associated with better outcome in patients with advanced atherosclerotic disease

JAL Meeuwsen, A van Duijvenvoorde… - Journal of the …, 2017 - Am Heart Assoc
Background Atherosclerosis is an inflammatory lipid disorder and the main underlying
pathology of acute ischemic events. Despite a vast amount of data from murine …