Targeted therapies such as oral tyrosine kinase inhibitors (TKIs) are the main therapeutic
strategy effective for advanced hepatocellular carcinoma (HCC). Currently six tyrosine …

Simple Summary The key factor in preventing premature death from cancer is an early and
accurate diagnosis. While common diagnostic procedures are successful in the detection …

Cytochrome P450 3A4 (CYP3A4), one of the most important members of the cytochrome
P450 subfamily, is a crucial catalyst in the metabolism of numerous drugs. As it catalyzes …

Objective: This study aimed to compare the safety profile of tyrosine kinase inhibitors (TKIs)
approved for use as monotherapy or combination therapy for the first-line treatment of adult …

The management of urothelial carcinoma (UC) has rapidly advanced in recent years with
new approvals for immune checkpoint inhibitors and antibody-drug conjugates. However …

Introduction Oral administration of ritonavir-boosted nirmatrelvir (Paxlovid) was found to be
promising in the treatment of coronavirus disease 2019. The active antiviral component …

Cancer therapy faces many challenges, such as inadequate drug loading, low solubility,
leakage before reaching the target cells and killing healthy cells. Furthermore, severe side …

Recently, it was established that ferroptosis, a type of iron-dependent regulated cell death,
plays a prominent role in radiotherapy-triggered cell death. Accordingly, ferroptosis inducers …

Patients with advanced or metastatic colorectal cancer ((m) CRC) have limited effective
treatment options resulting in high mortality rates. A better understanding of the molecular …

Osteonecrosis is a debilitating condition characterized by the loss of blood supply to the
bones, leading to bone death. This condition can impact various bones, including the jaw …