Coronavirus membrane fusion mechanism offers a potential target for antiviral development
Abstract The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …
Inhibitors of SARS-CoV-2 entry: current and future opportunities
Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2
has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological …
has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological …
[HTML][HTML] Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
J Liu, R Cao, M Xu, X Wang, H Zhang, H Hu, Y Li, Z Hu… - Cell discovery, 2020 - nature.com
Dear Editor, The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat …
Hydroxychloroquine and chloroquine for treatment of SARS-CoV-2 (COVID-19)
KA Pastick, EC Okafor, F Wang… - Open forum …, 2020 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral
infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and …
infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and …
[HTML][HTML] Lessons in self-defence: inhibition of virus entry by intrinsic immunity
S Majdoul, AA Compton - Nature Reviews Immunology, 2022 - nature.com
Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo
S Weston, CM Coleman, R Haupt, J Logue… - Journal of …, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the
end of 2019 and has rapidly caused a pandemic, with over 20 million recorded COVID-19 …
end of 2019 and has rapidly caused a pandemic, with over 20 million recorded COVID-19 …
[HTML][HTML] Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells
JK Millet, GR Whittaker - Virology, 2018 - Elsevier
During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
Fusion of enveloped viruses in endosomes
JM White, GR Whittaker - Traffic, 2016 - Wiley Online Library
Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …
Deletion of the SARS-CoV-2 spike cytoplasmic tail increases infectivity in pseudovirus neutralization assays
Pseudotyped viruses are valuable tools for studying virulent or lethal viral pathogens that
need to be handled in biosafety level 3 (BSL3) or higher facilities. With the explosive spread …
need to be handled in biosafety level 3 (BSL3) or higher facilities. With the explosive spread …
[HTML][HTML] Glycopeptide antibiotics potently inhibit cathepsin l in the late endosome/lysosome and block the entry of ebola virus, middle east respiratory syndrome …
N Zhou, T Pan, J Zhang, Q Li, X Zhang, C Bai… - Journal of Biological …, 2016 - ASBMB
Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans.
The outbreaks of Ebola viruses in 2014 represented the most serious Ebola epidemics in …
The outbreaks of Ebola viruses in 2014 represented the most serious Ebola epidemics in …