For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …

The use of animal models to study diseases is fundamental to the advancement of the
understanding of basic biologic mechanisms and disease-specific dysfunctions and to the …

Human genome wide association studies (GWAS) have recently identified at least four new,
non-MHC-linked candidate genes or gene regions causing type one diabetes (T1D) …

Ubiquitously expressed CD38 and T cell-expressed ADP-ribosyltransferase 2 (ART2) are
ectoenzymes competing for NAD substrate. CD38 exerts pleiotropic actions in hemopoietic …

Although once widely anticipated to unlock how human type 1 diabetes (T1D) develops,
extensive study of the nonobese diabetic (NOD) mouse has failed to yield effective …

Monoclonal antibodies (mAbs) have emerged as a mainstream therapeutic option against
cancer. mAbs mediate tumor cell-killing through several mechanisms including complement …

Embryonic stem (ES) cells are derived from preimplantation stage mouse embryos at the
time when they have reached the blastocyst stage. It is at this point that the first steps of …

Interferon-producing killer dendritic cells (IKDC) were first described for their outstanding
anti-tumoral properties. The “IKDC” terminology implied the description of a novel DC subset …

In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in
part on autoreactive CD8+ T cells recognizing pancreatic β cell peptides presented by often …

Insulin resistance is a serious challenge in diabetes treatment. Around the world, several
plants are used in the treatment of diabetes and experimental studies clearly demonstrated …