Abstract Three-dimensional (3D) in vitro models have been used in cancer research as an
intermediate model between in vitro cancer cell line cultures and in vivo tumor. Spherical …

Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …

The invasion properties of glioblastoma hamper a radical surgery and are responsible for its
recurrence. Understanding the invasion mechanisms is thus critical to devise new …

To more accurately study the complex mechanisms behind cancer invasion, progression,
and response to treatment, researchers require models that replicate both the multicellular …

Spheroids initiated directly from human primary gliomas were used to investigate the effects
of EGF, bFGF, NGF and PDGF (bb) on cell proliferation, migration and invasion into foetal rat …

Brain tumors' severity ranges from benign to highly aggressive and invasive. Bioengineering
tools can assist in understanding the pathophysiology of these tumors from outside the body …

Object. The aim of this study was to develop an improved animal model for brain tumor
study. The need for better and more relevant brain tumor models is generally acknowledged …

OBJECTIVE: Glioblastoma multiforme is a malignant primary brain tumor associated with
short patient survival despite aggressive treatment, in part because of its propensity to …

Glioblastoma multiforme (GBM) tumors are one of the most deadly forms of human cancer
and despite improved treatments, median survival time for the majority of patients is a dismal …

Malignant gliomas are characterized by an extensive invasion of tumor cells into the normal
brain parenchyma. A substantial amount of data indicates that cell movement in general is …