Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

SW Hung, R Zhang, Z Tan, JPW Chung… - Medicinal research …, 2021 - Wiley Online Library
Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and
development of endometriotic cells in ectopic sites can be promoted via multiple pathways …

The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene …

M Samimi, MH Pourhanifeh… - Journal of cellular …, 2019 - Wiley Online Library
Endometriosis is a frequent and chronic illness in young women which could be defined by
the existence of endometrial stroma and glands outside of the normal site of the lining of the …

Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis

FM Reis, F Petraglia, RN Taylor - Human reproduction update, 2013 - academic.oup.com
BACKGROUND The recruitment of immune cells by chemokines and the regulation of
endometrial cell apoptosis are critical aspects of endometriosis biology. Here, we review the …

Self-renewing endometrial epithelial organoids of the human uterus

HC Fitzgerald, P Dhakal, SK Behura… - Proceedings of the …, 2019 - National Acad Sciences
The human endometrium is essential in providing the site for implantation and maintaining
the growth and survival of the conceptus. An unreceptive endometrium and disrupted …

L-arginine enhances cell proliferation and reduces apoptosis in human endometrial RL95-2 cells

JM Greene, JM Feugang, KE Pfeiffer, JV Stokes… - Reproductive Biology …, 2013 - Springer
Background L-arginine is considered to be one of the most versatile amino acids due to the
fact that it serves as a precursor for many important molecules in cellular physiology. When …

Apoptosis in human endometrium and endometriosis

T Harada, A Kaponis, T Iwabe… - Human reproduction …, 2004 - academic.oup.com
Apoptosis plays a critical role in maintaining tissue homeostasis and represents a normal
function to eliminate excess or dysfunctional cells. Accumulated evidence suggests that …

Curcumin and endometriosis

A Vallée, Y Lecarpentier - International journal of molecular sciences, 2020 - mdpi.com
Endometriosis is one of the main common gynecological disorders, which is characterized
by the presence of glands and stroma outside the uterine cavity. Some findings have …

Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis

WP Dmowski, J Ding, J Shen, N Rana… - Human …, 2001 - academic.oup.com
BACKGROUND: The aetiology of endometriosis is unknown. Ectopic dissemination of the
endometrial cells gives origin to endometriotic lesions, but occurs in women with and without …

Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-4

TE Vaskivuo, M Anttonen, R Herva… - The Journal of …, 2001 - academic.oup.com
The majority of oocytes present in fetal ovaries are depleted before birth, and only about 400
will ovulate during the normal fertile life span. Studies on animals have shown that apoptosis …

Endometriosis and adenomyosis: similarities and differences

J Donnez, CA Stratopoulou, MM Dolmans - Best Practice & Research …, 2024 - Elsevier
Deep endometriosis and uterine adenomyosis are two frequently encountered conditions
affecting approximately 200 million women worldwide. They are closely related, showing …