Synovial fibrosis involvement in osteoarthritis
L Zhang, R Xing, Z Huang, L Ding, L Zhang, M Li… - Frontiers in …, 2021 - frontiersin.org
Bone changes have always been the focus of research on osteoarthritis, but the number of
studies on synovitis has increased only over the last 10 years. Our current understanding is …
studies on synovitis has increased only over the last 10 years. Our current understanding is …
Targeting CD44 receptor pathways in degenerative joint diseases: Involvement of Proteoglycan-4 (PRG4)
MM Qadri - Pharmaceuticals, 2023 - mdpi.com
Rheumatoid arthritis (RA), osteoarthritis (OA), and gout are the most prevalent degenerative
joint diseases (DJDs). The pathogenesis underlying joint disease in DJDs remains unclear …
joint diseases (DJDs). The pathogenesis underlying joint disease in DJDs remains unclear …
Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis
PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …
COL3A1 and MMP9 serve as potential diagnostic biomarkers of osteoarthritis and are associated with immune cell infiltration
S Li, H Wang, Y Zhang, R Qiao, P Xia, Z Kong… - Frontiers in …, 2021 - frontiersin.org
Background Osteoarthritis (OA) is one of the most common age-related degenerative
diseases. In recent years, some studies have shown that pathological changes in the …
diseases. In recent years, some studies have shown that pathological changes in the …
Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
Background Synovial macrophages perform a multitude of functions that include clearance
of cell debris and foreign bodies, tissue immune surveillance, and resolution of …
of cell debris and foreign bodies, tissue immune surveillance, and resolution of …
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration
RJ Krawetz, S Abubacker, C Leonard… - NPJ Regenerative …, 2022 - nature.com
The wound healing response is one of most primitive and conserved physiological
responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the …
responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the …
Contribution of MicroRNA‐27b‐3p to Synovial Fibrotic Responses in Knee Osteoarthritis
Objective Synovial fibrosis contributes to osteoarthritis (OA) pathology, but the underlying
mechanisms remain unknown. We have observed increased microRNA‐27b‐3p (miR‐27b …
mechanisms remain unknown. We have observed increased microRNA‐27b‐3p (miR‐27b …
Healthy and osteoarthritis-affected joints facing the cellular crosstalk
S Semenistaja, S Skuja, A Kadisa, V Groma - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …
disease that is recognized as the most common type of arthritis. During the last decade, it …
Protein phosphatase 2A regulates xanthine oxidase-derived ROS production in macrophages and influx of inflammatory monocytes in a murine gout model
S Elsayed, KA Elsaid - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Gout is a common arthritis, due to deposition of monosodium urate (MSU)
crystals which results in IL-1β secretion by tissue-resident macrophages. Xanthine oxidase …
crystals which results in IL-1β secretion by tissue-resident macrophages. Xanthine oxidase …
Epigenetic regulation of nutrient transporters in rheumatoid arthritis fibroblast‐like synoviocytes
Objective Since previous studies indicate that metabolism is altered in rheumatoid arthritis
(RA) fibroblast‐like synoviocytes (FLS), we undertook this study to determine if changes in …
(RA) fibroblast‐like synoviocytes (FLS), we undertook this study to determine if changes in …