Bone changes have always been the focus of research on osteoarthritis, but the number of
studies on synovitis has increased only over the last 10 years. Our current understanding is …

Rheumatoid arthritis (RA), osteoarthritis (OA), and gout are the most prevalent degenerative
joint diseases (DJDs). The pathogenesis underlying joint disease in DJDs remains unclear …

PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …

Background Osteoarthritis (OA) is one of the most common age-related degenerative
diseases. In recent years, some studies have shown that pathological changes in the …

Background Synovial macrophages perform a multitude of functions that include clearance
of cell debris and foreign bodies, tissue immune surveillance, and resolution of …

The wound healing response is one of most primitive and conserved physiological
responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the …

Objective Synovial fibrosis contributes to osteoarthritis (OA) pathology, but the underlying
mechanisms remain unknown. We have observed increased microRNA‐27b‐3p (miR‐27b …

Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …

Background: Gout is a common arthritis, due to deposition of monosodium urate (MSU)
crystals which results in IL-1β secretion by tissue-resident macrophages. Xanthine oxidase …

Objective Since previous studies indicate that metabolism is altered in rheumatoid arthritis
(RA) fibroblast‐like synoviocytes (FLS), we undertook this study to determine if changes in …