Antitumor efficacy and safety of unedited autologous CD5. CAR T cells in relapsed/refractory mature T-cell lymphomas
LQC Hill, RH Rouce, MJ Wu, T Wang, R Ma, H Zhang… - Blood, 2024 - ashpublications.org
Despite newer targeted therapies, patients with primary refractory or relapsed (r/r) T-cell
lymphoma have a poor prognosis. The development of chimeric antigen receptor (CAR) T …
lymphoma have a poor prognosis. The development of chimeric antigen receptor (CAR) T …
Long‐term survivorship care after CAR‐T cell therapy
R Puckrin, K Jamani… - European Journal of …, 2024 - Wiley Online Library
While cytokine release syndrome and immune effector cell‐associated neurotoxicity
syndrome are well‐recognized acute toxicities of chimeric antigen receptor (CAR) T cell …
syndrome are well‐recognized acute toxicities of chimeric antigen receptor (CAR) T cell …
Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance
Adoptive cell therapies engineered to express chimeric antigen receptors (CARs) or
transgenic T cell receptors (TCRs) to recognize and eliminate cancer cells have emerged as …
transgenic T cell receptors (TCRs) to recognize and eliminate cancer cells have emerged as …
Human herpes virus-6 (HHV-6) reactivation after hematopoietic cell transplant and chimeric antigen receptor (CAR)-T cell therapy: a shifting landscape
HHV-6B reactivation affects approximately half of all allogeneic hematopoietic cell transplant
(HCT) recipients. HHV-6B is the most frequent infectious cause of encephalitis following …
(HCT) recipients. HHV-6B is the most frequent infectious cause of encephalitis following …
BCMA CAR-T cells in multiple myeloma–ready for take-off?
L Scheller, E Tebuka, PF Rambau, H Einsele… - Leukemia & …, 2024 - Taylor & Francis
Although the approval of new drugs has improved the clinical outcome of multiple myeloma
(MM), it was widely regarded as incurable over the past decades. However, recent …
(MM), it was widely regarded as incurable over the past decades. However, recent …
Hematopoiesis and immune reconstitution after CD19 directed chimeric antigen receptor T‐cells (CAR‐T): A comprehensive review on incidence, risk factors and …
Impaired function of hematopoiesis after treatment with chimeric antigen T‐cells (CAR‐T) is
a frequent finding and can interest a wide range of patients, regardless of age and …
a frequent finding and can interest a wide range of patients, regardless of age and …
Development and validation of an automated computational approach to grade immune effector cell-associated hematotoxicity
Hematologic toxicity frequently complicates chimeric antigen receptor (CAR) T-cell therapy,
resulting in significant morbidity and mortality. In an effort to standardize reporting, the …
resulting in significant morbidity and mortality. In an effort to standardize reporting, the …
[HTML][HTML] Innovative cellular therapies for autoimmune diseases: expert-based position statement and clinical practice recommendations from the EBMT practice …
R Greco, T Alexander, N Del Papa, F Müller… - …, 2024 - thelancet.com
Autoimmune diseases (ADs) are characterized by loss of immune tolerance, high chronicity,
with substantial morbidity and mortality, despite conventional immunosuppression (IS) or …
with substantial morbidity and mortality, despite conventional immunosuppression (IS) or …
Mechanisms and management of CAR T toxicity
CJ Ferreri, M Bhutani - Frontiers in Oncology, 2024 - frontiersin.org
Chimeric antigen receptor (CAR) T cell therapies have dramatically improved treatment
outcomes for patients with relapsed or refractory B-cell acute lymphoblastic leukemia, large …
outcomes for patients with relapsed or refractory B-cell acute lymphoblastic leukemia, large …
[HTML][HTML] Current Challenges in Chimeric Antigen Receptor T-cell Therapy in Patients With B-cell Lymphoid Malignancies
Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy based on
genetically engineered T cells derived from patients. The introduction of CAR T-cell therapy …
genetically engineered T cells derived from patients. The introduction of CAR T-cell therapy …