The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by
autoimmune regulator (Aire), is critical for the protection of peripheral tissues from …

Adaptive immune recognition is mediated by antigen receptors on B and T cells generated
by somatic recombination during lineage development. The high level of diversity resulting …

In addition to genomic mutations, RNA editing is another major mechanism creating
sequence variations in proteins by introducing nucleotide changes in mRNA sequences …

The immunoproteasome plays a key role in generation of HLA peptides for T cell-mediated
immunity. Integrative genomic and proteomic analysis of non-small cell lung carcinoma …

Immune checkpoint inhibitors (ICIs) are potentially life‐saving cancer therapies that can
trigger immune‐related adverse events (irAEs). irAEs can impact any organ and range in …

MHC class I-related molecule MR1 presents riboflavin-and folate-related metabolites to
mucosal-associated invariant T cells, but it is unknown whether MR1 can present alternative …

Most adaptive immune responses require the activation of specific T cells through the T cell
antigen receptor (TCR)–CD3 complex. Here we show that cholesterol sulfate (CS), a …

Aquaporin-4 (AQP4)-specific Th17 cells are thought to have a central role in neuromyelitis
optica (NMO) pathogenesis. When modeling NMO, only AQP4-reactive Th17 cells from …

Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate
target cells by direct cell–cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by …

Although critical to T cell function, antigen specificity is often omitted in high-throughput
multiomics-based T cell profiling due to technical challenges. We describe a high …