Lymph nodes (LNs) play critical roles in adaptive immunity by concentrating in one location
the antigens, antigen-presenting cells, and antigen-responsive lymphocytes involved in …

The successes of antitumor immuno-based therapies and the application of next-generation
sequencing to mutation profiling have produced insights into the specific targets of antitumor …

Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are two distinct autoimmune diseases
that manifest with chronic synovial inflammation. Here, we show that CD4+ T cells from …

Narcolepsy type 1 is a devastating neurological sleep disorder resulting from the destruction
of orexin-producing neurons in the central nervous system (CNS). Despite its striking …

One of the feats of adaptive immunity is its ability to recognize foreign pathogens while
sparing the self. During maturation in the thymus, T cells are selected through the binding …

The incomplete removal of T cells that are reactive against self-proteins during their
differentiation in the thymus requires mechanisms of tolerance that prevent their effector …

Oncolytic viruses (OVs) are multimodal cancer therapeutics, with one of their dominant
mechanisms being in situ vaccination. There is a growing consensus that optimal cancer …

Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including
discrimination between self-and non-self-antigens, containment of immunopathology, and …

Microbial infections often precede the onset of autoimmunity. How infections trigger
autoimmunity remains poorly understood. We investigated the possibility that infection might …

Highlights•Antibody-inducing vaccines against atherosclerosis are designed to induce
neutralizing antibodies.•Treg-inducing vaccines against atherosclerosis are designed to …