[HTML][HTML] Targeting PAI-1 in cardiovascular disease: structural insights into PAI-1 functionality and inhibition
M Sillen, PJ Declerck - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin)
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …
The biochemistry, physiology and pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo
B Van De Craen, PJ Declerck, A Gils - Thrombosis research, 2012 - Elsevier
Plasminogen activator inhibitor-1 (PAI-1) is the primary physiological inhibitor of both tissue-
type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) and is …
type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) and is …
The pro‐or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
L Devy, S Blacher, C Grignet-Debrus… - The FASEB …, 2002 - Wiley Online Library
ABSTRACT Plasminogen activator inhibitor 1 (PAI‐1) is believed to control proteolytic
activity and cell migration during angiogenesis. We previously demonstrated in vivo that this …
activity and cell migration during angiogenesis. We previously demonstrated in vivo that this …
Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis
HC Kwaan, J Wang, K Svoboda, PJ Declerck - British journal of cancer, 2000 - nature.com
Abstract Plasminogen activator inhibitor 1 (PAI-1) has been found to be a bad prognostic
factor in a number of tumours but the reason has not been fully explained. The human …
factor in a number of tumours but the reason has not been fully explained. The human …
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing
angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL …
angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL …
Plasminogen activator inhibitor-1
A Gils, PJ Declerck - Current medicinal chemistry, 2004 - ingentaconnect.com
Plasminogen activator inhibitor-1 (PAI-1) is an important component of the
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
Structures of active and latent PAI-1: a possible stabilizing role for chloride ions
TJ Stout, H Graham, DI Buckley, DJ Matthews - Biochemistry, 2000 - ACS Publications
Serpins exhibit a range of physiological roles and can contribute to certain disease states
dependent on their various conformations. Understanding the mechanisms of the large …
dependent on their various conformations. Understanding the mechanisms of the large …
Molecular mechanisms of vaspin action–from adipose tissue to skin and bone, from blood vessels to the brain
Visceral adipose tissue-derived serine protease inhibitor (vaspin) or SERPINA12 according
to the serpin nomenclature was identified together with other genes and gene products that …
to the serpin nomenclature was identified together with other genes and gene products that …
The structural basis for the pathophysiological relevance of PAI-1 in cardiovascular diseases and the development of potential PAI-1 inhibitors
A Gils, PJ Declerck - Thrombosis and haemostasis, 2004 - thieme-connect.com
Plasminogen activator inhibitor-1 (PAI-1) is an important component of the
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type …
Inhibition of apoptosis and caspase‐3 in vascular smooth muscle cells by plasminogen activator inhibitor type‐1
Y Chen, RJ Kelm Jr, RC Budd, BE Sobel… - Journal of cellular …, 2004 - Wiley Online Library
Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with
decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters …
decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters …