The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

Extracellular vesicles have emerged as prominent regulators of the immune response
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …

INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

The mechanical properties of cells influence their cellular and subcellular functions,
including cell adhesion, migration, polarization, and differentiation, as well as organelle …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …