Goals and targets for personalized therapy for HCC

T Couri, A Pillai - Hepatology international, 2019 - Springer
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality
worldwide and its incidence continues to rise. While cirrhosis underlies most cases of HCC …

Pathogenesis and current treatment strategies of hepatocellular carcinoma

D Tümen, P Heumann, K Gülow, CN Demirci… - Biomedicines, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

G Khemlina, S Ikeda, R Kurzrock - Molecular cancer, 2017 - Springer
Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is a leading
cause of cancer-related death worldwide. It is highly refractory to most systemic therapies …

Cancer stem cell functions in hepatocellular carcinoma and comprehensive therapeutic strategies

YC Liu, CT Yeh, KH Lin - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

Advances in targeted therapies for hepatocellular carcinoma in the genomic era

JM Llovet, A Villanueva, A Lachenmayer… - Nature reviews Clinical …, 2015 - nature.com
Mortality owing to liver cancer has increased in the past 20 years, and the latest estimates
indicate that the global health burden of this disease will continue to grow. Most patients with …

EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma

European Association For The Study Of … - Journal of …, 2012 - journal-of-hepatology.eu
EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular
carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies …

CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part I. Development, growth, and spread: key pathologic and imaging aspects

JY Choi, JM Lee, CB Sirlin - Radiology, 2014 - pubs.rsna.org
Computed tomography (CT) and magnetic resonance (MR) imaging play critical roles in the
diagnosis and staging of hepatocellular carcinoma (HCC). The first article of this two-part …

[HTML][HTML] EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma

EO for Research… - Journal of …, 2012 - Elsevier
EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular
carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies …

NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis

JG O'leary, KR Reddy, G Garcia‐Tsao, SW Biggins… - Hepatology, 2018 - journals.lww.com
Several highly effective, interferon‐free, direct‐acting antiviral (DAA)‐based regimens are
available for the treatment of chronic hepatitis C virus (HCV) infection. Despite impressive …

Sorafenib in advanced hepatocellular carcinoma

JM Llovet, S Ricci, V Mazzaferro… - New England journal …, 2008 - Mass Medical Soc
Background No effective systemic therapy exists for patients with advanced hepatocellular
carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the …