[HTML][HTML] Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach
The four Janus kinase (JAK) proteins and seven signal transducer and activator of
transcription (STAT) transcription factors mediate intracellular signal transduction …
transcription (STAT) transcription factors mediate intracellular signal transduction …
[HTML][HTML] Macrophage polarization and plasticity in systemic lupus erythematosus
MM Ahamada, Y Jia, X Wu - Frontiers in immunology, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every
organ. The condition mostly happens to adults but is also found in children, and the latter …
organ. The condition mostly happens to adults but is also found in children, and the latter …
From systemic lupus erythematosus to lupus nephritis: The evolving road to targeted therapies
M Xipell, GM Lledó, AC Egan, F Tamirou… - Autoimmunity …, 2023 - Elsevier
Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of
tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue …
tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue …
Anifrolumab, a monoclonal antibody to the type I interferon receptor subunit 1, for the treatment of systemic lupus erythematosus: an overview from clinical trials
Y Tanaka, R Tummala - Modern Rheumatology, 2021 - academic.oup.com
Chronic activation of the type I interferon (IFN) pathway plays a critical role in systemic lupus
erythematosus (SLE) pathogenesis. Anifrolumab is a human monoclonal antibody to the …
erythematosus (SLE) pathogenesis. Anifrolumab is a human monoclonal antibody to the …
[HTML][HTML] Association of viral infection with the development and pathogenesis of systemic lupus erythematosus
S Iwata, Y Tanaka - Frontiers in Medicine, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes multiple organ
damage in women of childbearing age and has a relapsing-remitting course. SLE is caused …
damage in women of childbearing age and has a relapsing-remitting course. SLE is caused …
The efficacy and safety of telitacicept for the treatment of systemic lupus erythematosus: a real life observational study
R Chen, R Fu, Z Lin, C Huang, W Huang - Lupus, 2023 - journals.sagepub.com
Objective To investigate the efficacy and safety of telitacicept treatment in a Chinese SLE
cohort, with real-life settings. Methods All patients with SLE who were receiving telitacicept …
cohort, with real-life settings. Methods All patients with SLE who were receiving telitacicept …
[HTML][HTML] Why do we need JAK inhibitors in systemic lupus erythematosus?
Systemic lupus erythematosus (SLE) is a chronic, multifactorial autoimmune disease with
complex pathogenesis characterized by the imbalance of pro-inflammatory and anti …
complex pathogenesis characterized by the imbalance of pro-inflammatory and anti …
[HTML][HTML] Cytokines in systemic lupus erythematosus—focus on TNF-α and IL-17
P Richter, LA Macovei, IR Mihai, A Cardoneanu… - International Journal of …, 2023 - mdpi.com
Systemic lupus erythematosus (SLE) is an autoimmune disorder known for its complex
pathogenesis, in which cytokines play an essential role. It seems that the modulation of …
pathogenesis, in which cytokines play an essential role. It seems that the modulation of …
[HTML][HTML] Current treatment approach, emerging therapies and new horizons in systemic lupus erythematosus
P Athanassiou, L Athanassiou - Life, 2023 - mdpi.com
Systemic lupus erythematosus (SLE), the prototype of systemic autoimmune diseases is
characterized by extreme heterogeneity with a variable clinical course. Renal involvement …
characterized by extreme heterogeneity with a variable clinical course. Renal involvement …
An enhanced mitochondrial function through glutamine metabolism in plasmablast differentiation in systemic lupus erythematosus
MH Sumikawa, S Iwata, M Zhang, H Miyata… - …, 2022 - academic.oup.com
Objective To evaluate the dysfunction of B-cell metabolism and its involvement in SLE
pathology. Methods We assessed the expression of metabolic markers of B cells in the …
pathology. Methods We assessed the expression of metabolic markers of B cells in the …