Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Pyroptosis is a form of programmed cell death activated by various stimuli and is
characterized by inflammasome assembly, membrane pore formation, and the secretion of …

Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of
inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the …

Some scholars have recently developed the concept of PANoptosis in the study of infectious
diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein …

Background Inflammatory response has been recognized as a pivotal pathophysiological
process during cerebral ischemic stroke. NLRP3 inflammasome, involved in the regulation …

Background Cold exposure is one of the most important risk factors for atrial fibrillation (AF),
and closely related to the poor prognosis of AF patients. However, the mechanisms …

Cathepsin B (CTSB), a member of lysosomal cathepsin, is involved in cell autophagy and
apoptosis. We previously reported that CTSB increased cardiomyocyte apoptosis in mice …

Inflammation promotes the development of heart failure (HF). The inflammasome is a
multimeric protein complex that plays an essential role in the innate immune response by …

Sepsis is an abnormal condition with multiple organ dysfunctions caused by the
uncontrolled infection response and one of the major diseases that seriously hang over …

Pulmonary hypertension (PH) is a clinical and pathophysiological syndrome caused by
changes in pulmonary vascular structure or function that results in increased pulmonary …