Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons …

Freezing of gait (FoG) is a profoundly disruptive gait disturbance in Parkinson's disease,
causing unintended stops while walking. Therapies for FoG reveal modest and transient …

Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

Baroreflex Dysfunction Baroreflexes play both an adaptive and a homeostatic role,
maintaining blood pressure, heart rate, and blood volume within the normal range. Defects …

Chronic neurological diseases are the leading cause of disability globally. Yet, our health-
care systems are not designed to meet the needs of many patients with chronic neurological …

Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

Alzheimer's disease (AD), which is characterized by the presence of amyloid-β (Aβ) plaques
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …

Background: We aimed to predict Montreal Cognitive Assessment (MoCA) scores in
Parkinson's disease patients at year 4 using handcrafted radiomics (RF), deep (DF), and …

An accumulating body of evidence suggests that the bacterium Akkermansia muciniphila
exhibits positive systemic effects on host health, mainly by improving immunological and …

Importance The average life expectancy has increased substantially in the past few decades
in most industrialized countries; however, not all of the increased life expectancy is being …