Autism spectrum disorder (ASD) refers to complex neurobehavioral and
neurodevelopmental conditions characterized by impaired social interaction and …

The efficacy and safety of dual orexin receptor antagonists (DORAs) for primary insomnia
have been well verified in several large randomized controlled trials (RCTs) over the past …

The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific
research following the discovery that this family plays a crucial role in a variety of …

From an anatomical point of view the neocortex is subdivided into up to six layers depending
on the cortical area. This subdivision has been described already by Meynert and Brodmann …

Orexin‐A and orexin‐B, also named hypocretin‐1 and hypocretin‐2, are two hypothalamic
neuropeptides highly conserved across mammalian species. Their effects are mediated by …

Abstract Purpose of Review We review recent evidence on the use of orexin receptor
antagonists (ORAs) for treating insomnia. We evaluate studies on five dual ORAs and one …

At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-
B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were …

Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …

Cognitive impairments and circadian rhythm disorders are the main clinical manifestations of
Alzheimer's disease (AD). Orexin has been reported as abnormally elevated in the …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
progressive and selective death of dopaminergic neurons. Orexin-A is involved in many …