In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Metabolism in immune cells is no longer thought of as merely a process for adenosine
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

HIF1α is a common component of pathways involved in the control of cellular metabolism
and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for …

Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …

The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated
in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer …

Reactive oxygen and nitrogen species (RONS) are essential for normal physiological
processes and play important roles in cell signaling, immunity, and tissue homeostasis …