Covering: up to April 2014 The development of drugs with broad-spectrum antiviral activities
is a long pursued goal in drug discovery. It has been shown that blocking co-opted host …

Cell membranes are very complex biological systems including a large variety of lipids and
proteins. Therefore, they are difficult to extract and directly investigate with biophysical …

Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in
cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein …

In addition to the appearance of senile plaques and neurofibrillary tangles, Alzheimer's
disease (AD) is characterized by aberrant lipid metabolism and early mitochondrial …

Macrophages, as professional phagocytes of the immune system, possess the ability to
detect and clear invading pathogens and apoptotic cells through phagocytosis …

Sphingolipids comprise a major class of structural materials and lipid signaling molecules in
all eukaryotic cells. Over the past two decades, there has been a phenomenal growth in the …

Lipids are fundamental building blocks of all cells and play important roles in the
pathogenesis of different diseases, including inflammation, autoimmune disease, cancer …

The molecular mechanisms controlling the adaptation of viruses to host cells are generally
poorly documented. An essential issue to resolve is whether host membranes, and …

Visceral leishmaniasis (VL) is caused by various species of the genus Leishmania.
Internalization of Leishmania into host cells is facilitated by a large number of receptors, and …

Lipid rafts form signaling platforms on biological membranes with incompletely
characterized role in immune response to infection. Here we report that lipid-raft …