Atrial fibrillation (AF) is the most common sustained arrhythmia with a prevalence of up to
4% and an upwards trend due to demographic changes. It is associated with an increase in …

Zebrafish heart has evolved as an intensely studied model for cardiac development,
physiology and pathophysiology. A particular advantage is its morphological and functional …

Work over the past three decades has greatly advanced our understanding of the regulation
of Kir K+ channels by polyanionic lipids of the phosphoinositide (eg, PIP2) and fatty acid …

Cardiomyocytes express a surprisingly large number of potassium channel types. The
primary physiological functions of the currents conducted by these channels are to maintain …

Understanding molecular mechanisms involved in atrial tissue remodeling and
arrhythmogenesis in atrial fibrillation (AF) is essential for developing specific therapeutic …

TASK-1 channels have emerged as promising drug targets against atrial fibrillation, the most
common arrhythmia in the elderly. While TASK-3, the closest relative of TASK-1, was …

Patients with heart failure often develop cardiac arrhythmias. The mechanisms and
interrelations linking heart failure and arrhythmias are not fully understood. Historically …

The improvement of treatment strategies in cardiovascular medicine is an ongoing process
that requires constant optimization. The ability of a therapeutic intervention to prevent …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Previous genome-
wide association studies had identified single-nucleotide polymorphisms in several genomic …

The two-pore domain potassium (K+) channel TWIK-1 (or K 2P 1.1) contributes to
background K+ conductance in diverse cell types. TWIK-1, encoded by the KCNK1 gene, is …