The current kinetics of two-pore domain potassium (K 2P) channels resemble those of the
steady-state K+ currents being active during the plateau phase of cardiac action potentials …

There is a clear unmet medical need for new pharmacologic therapies with improved
efficacy and safety for the treatment of atrial fibrillation. Considerable research efforts have …

Background Recently, our laboratory presented functional and molecular evidence for the
presence of 2 competing sinoatrial node (SAN) pacemakers in healthy human and rat …

Gadiforms such as Atlantic haddock comprise some of the world's most economically
important fisheries. Understanding the early life history of these fish is a prerequisite for …

Rationale The neurokinin-III receptor was recently shown to regulate atrial cardiomyocyte
excitability by inhibiting atrial background potassium currents. TASK-1 (hK 2P 3.1) two-pore …

As one important member of the two-pore-domain potassium channel (K 2P) family,
potassium channel subfamily K member 3 (KCNK3) has been reported for thermogenesis …

Atrial fibrillation (AF) is a common arrhythmia with significant morbidities and only partially
adequate therapeutic options. AF is associated with atrial remodeling processes, including …

EC coupling is subjected to a mechanical feedback, which originates from physical force-
sensing ion channels in the pericardium and elsewhere. Reviewed here are the most recent …

KCNK3 is a two-pore-domain (K 2P) potassium channel involved in maintaining ion
homeostasis, mediating thermogenesis, controlling breath and modulating electrical …

Tandem pore domain acid-sensitive K+ (TASK) channels are present in cardiac tissue;
however, their contribution to cardiac pathophysiology is not well understood. Here, we …