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Abstract Human K 2P 17.1 (TASK-4, TALK-2) two-pore-domain potassium (K 2P) channels
have recently been implicated in heart rhythm disorders including atrial fibrillation and …

Work of the past three decades provided tremendous insight into the regulation of K+
channels-in particular Kir channels-by polyanionic lipids of the phosphoinositide (eg PIP2) …

Objective: The study analyzed the levels of estradiol, testosterone, homocysteine, uric acid
and cystatin-C in postmenopausal women with non-valvular atrial fibrillation. The main …

Two-pore domain (K2P) channels are twofold symmetric K+ channels which control cell
excitability by enabling the leak of potassium ions from cells in response to physicochemical …

Discussion In line with these results, Wiedmann et al., found that chronic in vivo inhibition of
TASK-1 (for 14 days) in a porcine model of persistent AF was associated with an increase in …

The cardiac excitation-contraction cycle relies critically on the spatio-temporal control of
intracellular Ca2+ release and sequestration in the sarcoplasmic reticulum (SR)(1). In …

Atrial fibrillation (AF) is the most common cardiac arrhythmia causing morbidity and mortality.
Despite recent advances, developing effective and safe anti-AF pharmaceutical therapies …

Pathological neuroinflammation contributes to the negative impact and adverse outcomes of
CNS autoimmune diseases, traumatic brain injury, stroke, and neurodegeneration. T …

BACKGROUND: KCNMA1 encodes the α-subunit of the large-conductance Ca2+-activated
K+ channel, KCa1. 1, and lies within a linkage interval for atrial fibrillation (AF). Insights into …