Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Cancer is a disease with complex pathological process. Current chemotherapy faces
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …

Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …

Metastasis is the major cause of cancer death, and the development of therapy resistance is
common. The tumor microenvironment can confer chemotherapy resistance …

Brain malignancies encompass a range of primary and metastatic cancers, including low-
grade and high-grade gliomas and brain metastases (BrMs) originating from diverse …

Background Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of
toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated …

Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …

Chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable outcomes in
individuals with hematological malignancies, but its success has been hindered by barriers …