Immunomodulatory effect of adipose-derived stem cells: the cutting edge of clinical application

S Ceccarelli, P Pontecorvi, E Anastasiadou… - Frontiers in cell and …, 2020 - frontiersin.org
Adipose-derived stem cells (ASCs) represent a promising tool for soft tissue engineering as
well as for clinical treatment of inflammatory and autoimmune pathologies. The well …

Genetic stability of mesenchymal stromal cells for regenerative medicine applications: a fundamental biosafety aspect

S Neri - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem/stromal cells (MSC) show widespread application for a variety of clinical
conditions; therefore, their use necessitates continuous monitoring of their safety. The risk …

Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model

M Khatri, LA Richardson, T Meulia - Stem cell research & therapy, 2018 - Springer
Background Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and
tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs) …

MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis

T Shigemoto-Kuroda, JY Oh, D Kim, HJ Jeong, SY Park… - Stem cell reports, 2017 - cell.com
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal
stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We …

[HTML][HTML] In situ delivery of apoptotic bodies derived from mesenchymal stem cells via a hyaluronic acid hydrogel: a therapy for intrauterine adhesions

L Xin, C Wei, X Tong, Y Dai, D Huang, J Chen, L Ma… - Bioactive materials, 2022 - Elsevier
Stem cell-based and stem cell-derived exosome-based therapies have shown promising
potential for endometrial regeneration and the clinical treatment of intrauterine adhesions …

Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy

F Li, J Wu, D Li, L Hao, Y Li, D Yi, KWK Yeung… - Journal of …, 2022 - Springer
Background Exosomes derived from stem cells have been widely studied for promoting
regeneration and reconstruction of multiple tissues as “cell-free” therapies. However, the …

Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease

R Okamoto, M Watanabe - Journal of gastroenterology, 2016 - Springer
In the past decades, continuous effort has been paid to deeply understanding the
pathophysiology of inflammatory bowel diseases (IBD), such as ulcerative colitis or Crohn's …

Immunomodulatory fibrous hyaluronic acid‐Fmoc‐diphenylalanine‐based hydrogel induces bone regeneration

M Halperin‐Sternfeld, A Pokhojaev… - Journal of Clinical …, 2023 - Wiley Online Library
Aim To investigate the potential of an ultrashort aromatic peptide hydrogelator integrated
with hyaluronic acid (HA) to serve as a scaffold for bone regeneration. Materials and …

Concise review: is cardiac cell therapy dead? Embarrassing trial outcomes and new directions for the future

JN Tang, J Cores, K Huang, XL Cui… - Stem Cells …, 2018 - academic.oup.com
Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of
cell therapy are mediated by both direct and indirect mechanisms. However, the application …

Injection‐free delivery of MSC‐derived extracellular vesicles for myocardial infarction therapeutics

J Tang, X Cui, Z Zhang, Y Xu, J Guo… - Advanced …, 2022 - Wiley Online Library
As emerging therapeutic factors, extracellular vesicles (EVs) offer significant potential for
myocardial infarction (MI) treatment. Current delivery approaches for EVs involve either intra …