Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Opioid use disorder is characterised by the persistent use of opioids despite the adverse
consequences of its use. The disorder is associated with a range of mental and general …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

North America is experiencing an unprecedented overdose crisis driven by the proliferation
of fentanyl and its analogues in the illicit drug supply. In 2018 there were 67,367 drug …

COVID-19 has turned the world upside down in a very short period of time. The impact of
COVID-19 will disproportionately effect people who are least able to protect themselves and …

Background People who use drugs (PWUD) may be at an increased risk of experiencing
negative effects related to COVID-19. Border and non-essential service closures may have …

Drug use represents a significant burden to public health through disease, disability and
social problems, and policy makers are becoming increasingly interested in how to develop …

Canada continues to experience an escalating opioid overdose crisis that has claimed more
than 8000 lives in the country since 2016. The presence of the synthetic opioid fentanyl and …

Background During a COVID-19 outbreak in the congregate shelter system in Halifax, Nova
Scotia, Canada, a healthcare team provided an emergency “safe supply” of medications and …

Background Injectable opioid agonist treatment (iOAT) was designed as a pragmatic and
compassionate approach for people who have not benefitted from medication assisted …