Extracellular vesicles have shown promising tissue recovery-promoting effects, making them
increasingly sought-after for their therapeutic potential in wound treatment. However …

Inflammation is one of the main pathological features leading to skin fibrosis and a key factor
leading to the progression of skin fibrosis. Acidosis caused by a decrease in extracellular pH …

Objectives: Explain the causes of keloid formation. Describe the most common populations
that develop keloid formation. Review the signs and symptoms of keloids. Outline the …

Keloids are an exuberant response to wound healing, characterized by an exaggerated
synthesis of collagen, probably due to the increase of fibroblasts activity and to the reduction …

Spherical nucleic acid (SNA), as a good gene delivery system, has a good application
prospect for transdermal administration in skin disorder treatment. However, most of the …

Pathological scarring is the greatest challenge after injury. Exosome from adipose-derived
mesenchymal stem cells has been reported effective to improve hypertrophic scar. This …

Stem cells have potential utility in wound therapy, however the benefits are often limited due
to cell injury from shear stress during injection and poor retention at the wound site. Here …

Objectives: Outline the presentation of limited scleroderma and systemic sclerosis. Identify
the most common cause of death in patients with scleroderma. Summarize the management …

One primary focus of skin tissue engineering has been the creation of innovative
biomaterials to facilitate rapid wound healing. Extracellular matrix (ECM), an essential …

Despite rapid progress in our understanding of wound pathobiology, transformative
developments in the care of acute and chronic cutaneous wounds have been elusive. Thus …