Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

How distal cis-regulatory elements (eg, enhancers) communicate with promoters remains an
unresolved question of fundamental importance. Although transcription factors and cofactors …

Abstract The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein
critical for viral genome packaging, yet the molecular details that underlie this process are …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …

Enhancers are cis-regulatory elements in the genome that cooperate with promoters to
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …

The bromodomain (BrD) is a conserved structural module found in chromatin-and
transcription-associated proteins that acts as the primary reader for acetylated lysine …

Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …

The coactivator p300/CREB-binding protein (CBP) regulates genes by facilitating the
assembly of transcriptional machinery and by acetylating histones and other factors …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …