In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

The ECM (extracellular matrix) is a major component of the vascular microenvironment that
modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen …

Genome-wide association studies (GWASs) across thousands of traits have revealed the
pervasive pleiotropy of trait-associated genetic variants. While methods have been …

The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast
maturation via a process called mechanosensing. Although in the aging male heart, ECM is …

Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disease caused by nuclear
envelope alterations that lead to accelerated aging and premature death. Several studies …

Mesenteric metastases in small intestinal neuroendocrine tumors (SI-NETs) are associated
with mesenteric fibrosis (MF) in a proportion of patients. MF can induce severe abdominal …

Abstract Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix
glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and …

Conclusions: The microfibrillar-associated protein 4+-activated HSC-derived LFMG
signature classifies patients with liver fibrosis with distinct clinical and biological …

Abdominal aortic aneurysm (AAA) is a progressive dilatation of the aorta that can lead to
aortic rupture. The pathophysiology of the disease is not well characterized but is known to …

Cardiovascular diseases (CVDs) pose a significant global health threat due to their complex
pathogenesis and high incidence, imposing a substantial burden on global healthcare …