Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Background Preliminary reports have described significant procoagulant events in patients
with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism …

Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

The purpose of this review is to summarize the research progress of PI3K/Akt signaling
pathway in erythropoiesis and glycolysis. Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …

Background Current anemia therapies for patients with non–dialysis-dependent CKD may
require injection and medical visits. Roxadustat, an oral hypoxia-inducible factor prolyl …

Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel–
Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell …

Background Roxadustat, an orally administered hypoxia-inducible factor prolyl hydroxylase
inhibitor, is being evaluated for treatment of anaemia of chronic kidney disease (CKD) …

Anemia is a frequent comorbidity of chronic kidney disease (CKD) and is associated with a
considerable burden because of decreased patient health-related quality of life and …

Introduction Roxadustat is an orally administered hypoxia-inducible factor prolyl hydroxylase
inhibitor being developed for the treatment of anemia of chronic kidney disease (CKD). This …

Hypoxia is an inherent pathophysiological characteristic of chronic kidney disease (CKD),
which is closely associated with the development of renal inflammation and fibrosis, as well …