Distance-based support vector machine to predict DNA N6-methyladenine modification

H Zhang, Q Zou, Y Ju, C Song, D Chen - Current Bioinformatics, 2022 - ingentaconnect.com
Background: DNA N6-methyladenine plays an important role in the restriction-modification
system to isolate invasion from adventive DNA. The shortcomings of the high time …

[HTML][HTML] Identify DNA-binding proteins through the extreme gradient boosting algorithm

Z Zhao, W Yang, Y Zhai, Y Liang, Y Zhao - Frontiers in Genetics, 2022 - frontiersin.org
The exploration of DNA-binding proteins (DBPs) is an important aspect of studying
biological life activities. Research on life activities requires the support of scientific research …

[HTML][HTML] A first computational frame for recognizing heparin-binding protein

W Zhu, SS Yuan, J Li, CB Huang, H Lin, B Liao - Diagnostics, 2023 - mdpi.com
Heparin-binding protein (HBP) is a cationic antibacterial protein derived from multinuclear
neutrophils and an important biomarker of infectious diseases. The correct identification of …

Decoding Connectivity Map-based drug repurposing for oncotherapy

Y Zhao, X Chen, J Chen, X Qi - Briefings in Bioinformatics, 2023 - academic.oup.com
The rising global burden of cancer has driven considerable efforts into the research and
development of effective anti-cancer agents. Fortunately, with impressive advances in …

[HTML][HTML] Bitter-RF: a random forest machine model for recognizing bitter peptides

YF Zhang, YH Wang, ZF Gu, XR Pan, J Li… - Frontiers in …, 2023 - frontiersin.org
Introduction Bitter peptides are short peptides with potential medical applications. The huge
potential behind its bitter taste remains to be tapped. To better explore the value of bitter …

NmRF: identification of multispecies RNA 2'-O-methylation modification sites from RNA sequences

C Ao, Q Zou, L Yu - Briefings in bioinformatics, 2022 - academic.oup.com
O-methylation (Nm) is a post-transcriptional modification of RNA that is catalyzed by 2'-O-
methyltransferase and involves replacing the H on the 2′-hydroxyl group with a methyl …

[HTML][HTML] Identification of cyclin protein using gradient boost decision tree algorithm

H Zulfiqar, SS Yuan, QL Huang, ZJ Sun, FY Dao… - Computational and …, 2021 - Elsevier
Cyclin proteins are capable to regulate the cell cycle by forming a complex with cyclin-
dependent kinases to activate cell cycle. Correct recognition of cyclin proteins could provide …

Deep-4mCW2V: A sequence-based predictor to identify N4-methylcytosine sites in Escherichia coli

H Zulfiqar, ZJ Sun, QL Huang, SS Yuan, H Lv, FY Dao… - Methods, 2022 - Elsevier
Abstract N4-methylcytosine (4mC) is a type of DNA modification which could regulate
several biological progressions such as transcription regulation, replication and gene …

[HTML][HTML] iTTCA-RF: a random forest predictor for tumor T cell antigens

S Jiao, Q Zou, H Guo, L Shi - Journal of translational medicine, 2021 - Springer
Background Cancer is one of the most serious diseases threatening human health. Cancer
immunotherapy represents the most promising treatment strategy due to its high efficacy and …

RGCNCDA: relational graph convolutional network improves circRNA-disease association prediction by incorporating microRNAs

Y Chen, Y Wang, Y Ding, X Su, C Wang - Computers in Biology and …, 2022 - Elsevier
Recently, a large number of studies have indicated that circRNAs with covalently closed
loops play important roles in biological processes and have potential as diagnostic …