[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Atrial myopathy

MJ Shen, R Arora, J Jalife - JACC: Basic to Translational Science, 2019 - jacc.org
This paper discusses the evolving concept of atrial myopathy by presenting how it develops
and how it affects the properties of the atria. It also reviews the complex relationships among …

The role of oxidative stress in cardiovascular aging and cardiovascular diseases

C Izzo, P Vitillo, P Di Pietro, V Visco, A Strianese… - Life, 2021 - mdpi.com
Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

A review of the molecular mechanisms underlying cardiac fibrosis and atrial fibrillation

G Sygitowicz, A Maciejak-Jastrzębska… - Journal of Clinical …, 2021 - mdpi.com
The cellular and molecular mechanism involved in the pathogenesis of atrial fibrosis are
highly complex. We have reviewed the literature that covers the effectors, signal transduction …

Aging and atrial fibrillation: A vicious circle

P Gao, X Gao, B Xie, G Tse, T Liu - International Journal of Cardiology, 2023 - Elsevier
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia observed in clinical
practice. Its prevalence increases dramatically with advancing age. This review article …

Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice

F Piccirillo, M Carpenito, G Verolino, C Chello… - Mechanisms of ageing …, 2019 - Elsevier
Aging results in functional and structural changes in the cardiovascular system, translating
into a progressive increase of mechanical vessel stiffness, due to a combination of changes …

[HTML][HTML] Impact of the extent of low-voltage zone on outcomes after voltage-based catheter ablation for persistent atrial fibrillation

T Yamaguchi, T Tsuchiya, A Fukui, Y Kawano… - Journal of …, 2018 - Elsevier
Abstract Background Low-voltage zones (LVZs), as measured by electroanatomic mapping,
are thought to be associated with fibrosis. We reported the efficacy of atrial fibrillation (AF) …

Pathophysiology and clinical relevance of atrial myopathy

MRL Tubeeckx, GW De Keulenaer… - Basic Research in …, 2024 - Springer
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic
remodeling of the atria and is the substrate for development of atrial fibrillation, the most …

Melatonin to rescue the aged heart: antiarrhythmic and antioxidant benefits

M Segovia-Roldan, ER Diez… - Oxidative Medicine and …, 2021 - Wiley Online Library
Aging comes with gradual loss of functions that increase the vulnerability to disease,
senescence, and death. The mechanisms underlying these processes are linked to a …

[HTML][HTML] Liensinine improves AngII-induced vascular remodeling via MAPK/TGF-β1/Smad2/3 signaling

P Jia, D Chen, Y Zhu, M Wang, J Zeng, L Zhang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Liensinine (Lien, C 37 H 42 N 2 O 6) is an
alkaloid compound from plumula nelumbinis that demonstrates an antihypertensive effect …