The opioid crisis remains a major public health concern, causing significant morbidity and
mortality worldwide. Pain is frequently observed among individuals with opioid use disorder …

Background Chronic musculoskeletal pain (CMP) is a complex condition that is mainly
treated with analgesic drugs. However, antidepressant intervention is also an important …

Patients with chronic pain often develop comorbid depressive symptoms, which makes the
pain symptoms more complicated and refractory. However, the underlying mechanisms are …

Objective To determine whether a single low dose of esketamine administered after
childbirth reduces postpartum depression in mothers with prenatal depression. Design …

Serotonin, also known as 5-hydroxytryptamine (5-HT), is a key messenger that mediates
several central and peripheral functions in the human body. Emerging evidence indicates …

Chronic pain and depression are highly prevalent pathologies and cause a major
socioeconomic burden to society. Chronic pain affects the emotional state of the individuals …

The serotonin transporter (5-hydroxytryptamine transporter [5-HTT], Serotonin Transporter
(SERT), SLC6A4) modulates the activity of serotonin via sodium-dependent reuptake. Given …

In chronic inflammatory pain (CIP) and depression, neuroapoptosis has been identified as a
contributing factor. Electroacupuncture (EA) shows promise as an alternative therapy for this …

Knee osteoarthritis (KOA) is linked to an enhanced release of interleukin-6 (IL-6). Increased
levels of IL-6 are associated with greater pain and insomnia. While total knee arthroplasty …

Importance While abundant work has examined patient-level differences in antidepressant
treatment outcomes, little is known about the extent of clinician-level differences …