A myriad of physiological processes in mammals are influenced by estrogens and the
estrogen receptors (ERs), ERα and ERβ. As we reviewed previously, given the widespread …

The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades.
More than 650 million obese and 2 billion overweight individuals are currently living in the …

Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …

Background: Previous studies suggest that sex steroids influence colorectal cancer (CRC)
carcinogenesis. The oestrogen receptor β (ERβ) is the predominantly expressed ER in the …

Epithelial cells are tightly coupled together through specialized intercellular junctions,
including adherens junctions, desmosomes, tight junctions, and gap junctions. A growing …

Purpose Ten eleven translocation (TET) enzyme activity is essential for active DNA
demethylation in biological processes, and their altered expression has been observed in …

Cancer is the second leading cause of death worldwide, with 9.6 million people estimated to
have died of cancer in 2018. Excess body fat deposition is a risk factor for many types of …

Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use
them to optimize the health benefits and avoid adverse effects is a major challenge …

We aimed to assess the relationship between dietary soyfood and isoflavone intake and
colorectal cancer risk in a case-control study. A total of 901 colorectal cancer cases and …

Aim The role of oestrogen metabolism and action in colorectal cancer (CRC) is
controversial. An extensive review of the current literature, encompassing epidemiological …