[HTML][HTML] Frontotemporal pathology in motor neuron disease phenotypes: insights from neuroimaging

MC McKenna, P Corcia, P Couratier, WF Siah… - Frontiers in …, 2021 - frontiersin.org
Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

Outcome measures and biomarkers for clinical trials in hereditary spastic paraplegia: a scoping review

SF Siow, D Yeow, LI Rudaks, F Jia, G Wali, CM Sue… - Genes, 2023 - mdpi.com
Hereditary spastic paraplegia (HSP) is characterized by progressive lower limb spasticity.
There is no disease-modifying treatment currently available. Therefore, standardized …

Brain damage and gene expression across hereditary spastic paraplegia subtypes

KR Servelhere, TJR Rezende, FD de Lima… - Movement …, 2021 - Wiley Online Library
Background Spinal cord has been considered the main target of damage in hereditary
spastic paraplegias (HSPs), but mounting evidence indicates that the brain is also affected …

Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers

G Mulkerrin, MC França Jr, J Lope… - Expert review of …, 2022 - Taylor & Francis
Introduction Hereditary spastic paraplegias (HSP) include a clinically and genetically
heterogeneous group of conditions. Novel imaging modalities have been increasingly …

Tract-specific damage at spinal cord level in pure hereditary spastic paraplegia type 4: a diffusion tensor imaging study

FJ Navas-Sánchez, L Marcos-Vidal, DM de Blas… - Journal of …, 2022 - Springer
Background SPG4 is a subtype of hereditary spastic paraplegia (HSP), an upper motor
neuron disorder characterized by axonal degeneration of the corticospinal tracts and the …

Corticospinal tract and motor cortex degeneration in pure hereditary spastic paraparesis type 4 (SPG4)

FJ Navas-Sánchez, D Martin De Blas… - … Lateral Sclerosis and …, 2022 - Taylor & Francis
Objective: SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP)
caused by mutations in the SPAST gene. HSP is considered an upper motor neuron …

Relationship between brain white matter damage and grey matter atrophy in hereditary spastic paraplegia types 4 and 5

Y Tu, Y Liu, S Fan, J Weng, M Li… - European Journal of …, 2024 - Wiley Online Library
Background and purpose White matter (WM) damage is the main target of hereditary spastic
paraplegia (HSP), but mounting evidence indicates that genotype‐specific grey matter (GM) …

[PDF][PDF] The Neuroimaging Features of Frontotemporal Dementia

MC McKenna - 2023 - tara.tcd.ie
(FTLD) has been refined by robust computational imaging studies in recent years. This has
led to the characterisation of phenotype-1-16 and genotypeassociated 17-23 patterns of …