Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Update on Keratinocyte Carcinomas | New England Journal of Medicine Skip to main content The
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Response to immunotherapies can be variable and unpredictable. Pathology-based
phenotyping of tumors into 'hot'and 'cold'is static, relying solely on T-cell infiltration in single …

An invasive biopsy followed by histological staining is the benchmark for pathological
diagnosis of skin tumors. The process is cumbersome and time-consuming, often leading to …

Background Early diagnosis and subtype classification of basal cell carcinoma (BCC) are
crucial to reduce morbidity and optimize treatment. Good accuracy in differentiating BCC …

Optical coherence tomography (OCT) is a noninvasive optical imaging method that can
generate high‐resolution en face and cross‐sectional images of the skin in vivo to a …

Skin cancer is the most common form of cancer and is globally rising. Historically, the
diagnosis of skin cancers has depended on various conventional techniques which are of …

Microscopic evaluation of resected tissue plays a central role in the surgical management of
cancer. Because optical microscopes have a limited depth-of-field (DOF), resected tissue is …

Reflectance confocal microscopy (RCM) is a novel technology that provides noninvasive, in
vivo imaging of the skin at nearly histologic resolution. In 2016, the US Centers for Medicare …

Reflectance confocal microscopy (RCM) is a noninvasive imaging tool used for in vivo
visualization of the skin. It has been extensively studied for use in the evaluation of …